Acute interstitial nephritis
Description
- Immune-mediated inflammation of the tubulointerstitium, sparing glomeruli and vessels
- ~15-20% of biopsied AKI; the commonest cause of AKI with a bland-ish urine but sterile pyuria
- Latency after the culprit drug:
- Antibiotics: 3-14 days (shorter on re-exposure)
- NSAIDs: weeks to months
- PPIs: 10-11 weeks median, up to a year
- Not dose-dependent, not predictable - it is a hypersensitivity reaction
6 more sections, plus exam facts
Premium unlocks every note across every specialty, and the full exam fact library behind it.
Get premium access