Anti-GBM disease
Description
- Autoantibody against the glomerular and alveolar basement membrane -> RPGN +/- pulmonary haemorrhage
- The most aggressive glomerulonephritis - untreated, ESKD or death in weeks
Nomenclature
| Term | Meaning |
|---|---|
| Goodpasture syndrome | RPGN + pulmonary haemorrhage from any cause (ANCA vasculitis, SLE, IgA vasculitis, anti-GBM) |
| Goodpasture disease | RPGN + pulmonary haemorrhage + anti-GBM antibody - accounts for 20-40% of Goodpasture syndrome |
| Anti-GBM disease | The antibody-defined disease, with or without lung involvement |
- Distribution: pulmonary + renal 60-80%, renal only 20-40%, pulmonary only <10%
- A monophasic, one-hit disease - unlike ANCA vasculitis it rarely relapses
6 more sections, plus exam facts
Premium unlocks every note across every specialty, and the full exam fact library behind it.
Get premium access