Framing
- Drug-drug interactions arise through pharmacokinetic mechanisms (one drug altering another's absorption, metabolism via cytochrome P450 induction/inhibition, or excretion) or pharmacodynamic mechanisms (additive, synergistic, or antagonistic effects at the same or related receptor systems) - both mechanisms are relevant to predicting and preventing clinically significant interactions
- See for the specific issue of non-prescription and complementary medicine interactions, often missed given patients' tendency not to volunteer this information unprompted
What sits under this topic
- See and for organ-function-related pharmacokinetic interaction risk
- See for the cytochrome P450 mechanism underlying most pharmacokinetic interactions
- See for polypharmacy as a broader interaction risk factor
Study aid only. These notes are written with the help of AI. Not for guiding clinical decisions.