Pharmacology, Toxicology and Addiction MedicineTier 1Approach to a presentation

Associated with adverse drug interactions - arrhythmias

Red flags

  • QTc >500ms or increase >60ms from baseline - high torsades risk
  • Polymorphic VT / torsades de pointes
  • Wide-complex tachycardia after TCA or flecainide overdose
  • Bradyarrhythmia with hypotension (beta-blocker/CCB/digoxin)
  • Syncope temporally linked to a new QT-prolonging drug

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