Lipoprotein disorders
Framing
- Lipoprotein disorders range from common polygenic dyslipidaemia to monogenic familial hypercholesterolaemia - all converging on elevated atherogenic lipoprotein burden (predominantly LDL) as the modifiable driver of premature atherosclerotic cardiovascular disease
- Statins remain first-line lipid-lowering therapy for most patients, with add-on agents reserved for inadequate LDL response or statin intolerance - understanding statin mechanism and its main adverse effect (myopathy) underpins safe prescribing across this whole topic
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