Chronic myeloid leukaemia
Description
- MPN driven by a single lesion: t(9;22)(q34;q11) -> BCR::ABL1
- Triphasic if untreated: chronic -> accelerated -> blast phase
- >90% present in chronic phase, often incidentally on FBE
- Marrow is hypercellular but not failing - Hb and platelets preserved or high
- Cytopenias at diagnosis should prompt a search for another cause or advanced phase
- The proof-of-concept disease for targeted therapy - near-normal life expectancy on TKI
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