Cutaneous manifestations of systemic diseases - angioedema
Description
- Deep dermal/subcutaneous or submucosal swelling - non-pitting, no urticaria/pruritus in the mast-cell-independent forms
- Two mechanistic families with different treatment: mast-cell/histamine-mediated (responds to adrenaline/antihistamines) vs bradykinin-mediated (does not)
- Bradykinin forms - hereditary angioedema (HAE), acquired C1-inhibitor deficiency, ACE-inhibitor angioedema
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