Diffuse large B-cell lymphoma
Description
- Commonest lymphoma - ~30-40% of all NHL. Aggressive but curable
- Rapidly enlarging nodal or extranodal mass +/- B symptoms
- Extranodal in ~40%: GI (commonest), Waldeyer's ring, bone, testis, CNS, breast, skin
- De novo, or transformed from an indolent lymphoma ("Richter" from CLL, transformed follicular)
WHO-5 / ICC entities to separate out
- DLBCL NOS - the bulk; subdivided by cell of origin
- High-grade B-cell lymphoma with MYC and BCL2 rearrangement ("double-hit")
- BCL6 double-hit no longer part of the definition in WHO-5
- Primary mediastinal B-cell lymphoma - young F, bulky mediastinum, distinct biology/treatment
- Primary CNS lymphoma, primary testicular, intravascular, EBV+ DLBCL
- T-cell/histiocyte-rich large B-cell lymphoma
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