Disorders of coagulation or thrombosis - use of anticoagulants and antiplatelet agents
Classes and targets
- Anticoagulants act on the fibrin-rich venous thrombus; antiplatelets on the platelet-rich arterial thrombus
- Using the wrong class for the territory is a common exam trap - aspirin is not treatment for VTE, and a DOAC is not treatment for a coronary stent
| Class | Agents | Target |
|---|---|---|
| Vitamin K antagonist | Warfarin | II, VII, IX, X (+ protein C, S) |
| Direct thrombin inhibitor | Dabigatran; argatroban, bivalirudin (IV) | IIa |
| Direct Xa inhibitor | Apixaban, rivaroxaban, edoxaban | Xa |
| Antithrombin-dependent | UFH, enoxaparin, fondaparinux, danaparoid | Xa +/- IIa |
| COX-1 | Aspirin | TXA2 |
| P2Y12 | Clopidogrel, prasugrel, ticagrelor | ADP receptor |
| GPIIb-IIIa | Tirofiban, abciximab, eptifibatide | Final common aggregation step |
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