Hepatitis B and C management in context of newer therapies

HBV vs HCV side by side

The exam tests the two viruses side by side. The single most important contrast:

	HBV	HCV
Genome	Partially dsDNA, cccDNA + integration	ssRNA, cytoplasmic only
Curable?	No - suppression only	Yes - >95% SVR
Endpoint	HBsAg loss ("functional cure", ~1%/yr)	SVR12
Therapy	Indefinite nucleos(t)ide analogue	8-12 weeks oral DAA
Vaccine	Yes	No
HCC without cirrhosis	Yes (~20%) - integration	Essentially no
Post-cure surveillance	Continue if male >40 / female >50 at clearance	Only if cirrhotic at cure

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