Bone marrow aspirate and trephine

Role

Bone marrow aspiration and trephine biopsy sample the marrow for diagnosis, staging, and monitoring of haematological malignancy and marrow infiltration - a core haematological investigation (see bone marrow transplant for indications/complications, this note focuses on the haematology-specific interpretive framework)
Central to diagnosing and classifying acute and chronic leukaemias, lymphoma staging, myeloma workup, and unexplained cytopenia not adequately explained by peripheral causes

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