Principles of transfusion and bone marrow transplantation

Autologous vs allogeneic - two completely different operations

	Autologous	Allogeneic
Graft	Patient's own mobilised stem cells	Donor cells
Purpose	Rescue from otherwise lethal high-dose chemotherapy	Replace the marrow + graft-versus-tumour immune effect
GVHD	None	The central problem
Relapse	Higher - no immune effect, possible graft contamination	Lower
Transplant-related mortality	~1-3%	~10-30%
Age ceiling	~70-75	~70 with reduced-intensity conditioning

*Autologous transplant is intensive chemotherapy. Allogeneic transplant is immunotherapy.*

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