Hepatitis - drug induced
Description
- Drug-induced liver injury (DILI) - a diagnosis of exclusion, classified by pattern using the R-value (ALT/ULN divided by ALP/ULN):
- Hepatocellular (R>=5) - ALT-predominant
- Cholestatic (R<=2) - ALP-predominant
- Mixed (R 2-5)
- Intrinsic (dose-dependent, predictable) - e.g. paracetamol - vs idiosyncratic (dose-independent, unpredictable, immune-mediated) - the majority of other drug causes
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