Hyperthyroidism
Description
- Hyperthyroidism = gland overproducing. Thyrotoxicosis = excess hormone from any source
- Not interchangeable - thionamides only work if the gland is synthesising
Patterns
| Uptake | Tg | Course | |
|---|---|---|---|
| Graves | High, diffuse | inc | Relapsing |
| Toxic MNG / adenoma | High, focal | inc | Progressive, no remission |
| Destructive thyroiditis | Absent/low | inc | Hyper -> eu -> hypo -> recovery |
| Exogenous T4 | Absent | dec | Resolves on cessation |
- Graves = organ-specific autoimmunity with extrathyroidal disease
- Orbitopathy 30-50%, dermopathy ~0.5%, acropachy 0.1-1%
- Eye and skin disease run independently of thyroid function - controlling TFTs does not treat them
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