IgA nephropathy
Description
- Mesangial deposition of galactose-deficient IgA1 immune complexes -> mesangial proliferation and glomerular injury
- The most common primary chronic glomerular disease worldwide
- IgA vasculitis (Henoch-Schonlein purpura) is the systemic form - identical renal histology plus purpura, arthritis and abdominal pain
The classic presentation
- Synpharyngitic macroscopic haematuria - gross haematuria within 1-3 days of a mucosal infection (URTI, gastroenteritis)
- *This is the discriminator from PSGN, which has a 10-21 day latency and a low C3*
- Or asymptomatic microscopic haematuria + proteinuria on screening
- Complement is normal despite the immune-complex mechanism
6 more sections, plus exam facts
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