Principles of immunisation in the immunocompromised host

Overview

Immunisation in immunocompromised patients follows the general principle that live vaccines are contraindicated in significant immunosuppression (risk of vaccine-strain disease) while inactivated/non-live vaccines remain indicated and are often given more intensively (additional doses, closer monitoring of response) given reduced but still meaningful vaccine-induced protection
An increasingly important area given the growing population on immunosuppressive/biologic therapy, transplant recipients, and those with HIV or other immunodeficiencies

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