Laboratory investigations - antibodies associated with inflammatory myositis
Antibody families
- Antibodies used to define inflammatory neurological and neuromuscular syndromes - where the antibody often names the disease and dictates the treatment
- Two mechanistic families
- Cell-surface antigen (NMDAR, LGI1, AQP4, MuSK, AChR, gangliosides) -> directly pathogenic, antibody-depleting therapy works, good response
- Intracellular antigen (Hu, Yo, Ri, Ma2, GAD65, amphiphysin) -> T-cell mediated, antibody is a marker not the cause, poor response, strong cancer association
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