Laboratory tests - extractable nuclear antigen (ENA)
What it is
- A panel of antibodies to nuclear antigens that are "extractable" in saline - historically defined by the assay, not by biology
- A reflex test, ordered when the ANA is positive (and specifically requested when anti-Ro is suspected, since some assays miss it)
- Standard Australian panel: Ro (SSA), La (SSB), Sm, RNP, Scl-70 (topoisomerase I), Jo-1
- Extended panels add centromere, RNA polymerase III, PM-Scl, Ku, ribosomal P, fibrillarin, Mi-2, MDA5, TIF1-gamma
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