Liver disease - chronic
Description
- Cirrhosis = histological diagnosis: bands of fibrous tissue linking portal and central areas, destroying normal architecture
- Regenerative nodules + fibrosis -> inc intrahepatic resistance -> portal hypertension
- Two axes determine everything downstream
- Compensated vs decompensated
- Portal pressure (HVPG)
- Compensated advanced chronic liver disease (cACLD) is the modern framing
- Continuum, not a binary; can regress if the driver is removed
- Decompensation = ascites, variceal bleed, or overt encephalopathy (+/- jaundice, coagulopathy)
- Median survival drops from >12 years to ~2 years
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