Parathyroid hormone
Structure
- 84-aa peptide from chief cells of 4 parathyroid glands
- Secreted as pre-pro-PTH -> pro-PTH -> PTH(1-84)
- Biological activity resides in PTH(1-34) - the basis of teriparatide
- Plasma half-life 2-4 minutes -> intraoperative PTH monitoring works
- Acts through PTH1R (Gs/Gq GPCR) on osteoblasts and renal tubule
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