Pharmacokinetic-pharmacodynamic relationship interpretation (tachyphylaxis, active metabolites, receptor changes)
Core concept
- Pharmacokinetics (PK) = what the body does to the drug (absorption, distribution, metabolism, excretion -> concentration over time)
- Pharmacodynamics (PD) = what the drug does to the body (concentration -> effect) -- the PK/PD relationship can change independent of concentration
- Exam task: interpret a concentration-vs-effect graph where the relationship shifts, and identify the mechanism (tachyphylaxis, active metabolite, receptor change)
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