OncologyTier 2Topic

Processes of - immune evasion and immune surveillance

Immunoediting - three Es

  • Immunoediting - three E's
    • Elimination - immune surveillance destroys transformed cells
    • Equilibrium - dormancy; immune control without clearance (can last decades)
    • Escape - variants that evade control emerge and become clinically apparent
  • *Every clinical cancer has, by definition, already escaped* - immunotherapy attempts to restore elimination

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