Adult-onset Still disease (AOSD)
Description
- A systemic AUTOINFLAMMATORY disease - innate immunity, not autoantibodies
- *The four cardinal features*
- FEVER - quotidian (once or twice daily) spikes >39 degrees C, returning to normal between
- ARTHRITIS / ARTHRALGIA
- EVANESCENT SALMON-PINK MACULAR RASH
- LEUCOCYTOSIS WITH NEUTROPHILIA
- *A diagnosis of exclusion* - infection, malignancy and other connective tissue disease must be excluded first
- The adult counterpart of systemic juvenile idiopathic arthritis - now regarded as one disease across the age spectrum
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