Side effects of systemic cancer therapy - peripheral neuropathy
Overview
- Chemotherapy-induced peripheral neuropathy (CIPN) - a common, often dose-limiting toxicity of several drug classes
- Predominantly sensory, symmetric, distal, "glove and stocking" - numbness, tingling, pain, sometimes with motor/autonomic features depending on the agent
- A major driver of dose reduction, delay, or early cessation of otherwise effective chemotherapy - clinically significant beyond the symptom itself
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