Tests of haemolysis - haptoglobin
What it is
- An alpha-2 glycoprotein made by the liver whose only job is to bind free plasma haemoglobin
- *The most sensitive single marker of intravascular haemolysis*
- A LOW haptoglobin is the abnormal result - it is consumed, not produced, by haemolysis
- Normal range ~0.3-2.0 g/L (assay-dependent)
- Part of the haemolysis quartet: haptoglobin low, LDH high, unconjugated bilirubin high, reticulocytes high
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