Viral infections - human papilloma virus
Description
- Non-enveloped double-stranded DNA virus; >200 genotypes; infects basal keratinocytes via microtrauma
- Replication tied to keratinocyte differentiation -> no viraemia, no cell lysis -> poor innate immune signalling
Genotype groups
| Group | Types | Disease |
|---|---|---|
| Low-risk mucosal | 6, 11 | Anogenital warts, recurrent respiratory papillomatosis |
| High-risk mucosal | 16, 18 (+31/33/45/52/58) | Cervical, anal, vulval, vaginal, penile, oropharyngeal SCC |
| Cutaneous | 1, 2, 4 | Common, plantar, plane warts |
| Beta-HPV | 5, 8 | Epidermodysplasia verruciformis; SCC in immunosuppressed |
- HPV16 + 18 cause ~70% of cervical cancer; HPV16 alone causes ~90% of HPV-positive oropharyngeal cancer
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